The first thing to check on Face Refinement is the Skin Mask. Make sure Skin Mask is on and click the Show Mask checkbox. Make sure the face is actually being outlined. I suspect you have a bad track, so you'll need to retrack it.
On rare cases, I'll have cases where for whatever reason, Face Refinement won't work, but I need to add more detail and/or an eyelight to a face. I use two oval windows in one node for brightening and/or sharpening, then a larger window with a nose cut out in the middle as a mask, and the latter is an eyelight. Each of these has to be tracked individually. I try very hard to barely touch brightning or sharpening, but I do add some eyelight on occasion.