I would do it all as UHD and then downrez at the end for HD delivery. The usual philosophy seems to be do the entire timeline at the highest resolution you're dealing with, then make sure "Force Debayer Res to Highest Quality" and "Force Sizing to Highest Quality" are checked off.
Kevin Cannon of Prehistoric Digital has some good advice about Input/Output Sizing settings at this link:
http://liftgammagain.com/forum/index.ph ... apes.5217/You can always play back at 1/2-res or 1/4-res for monitoring purposes, then switch it back to full for the final render.