Well I just did that and it seems to have worked. I think there was something wrong with that specific frame because there was a single black pixel where there should not have been one. I tried to clone it out and it showed through the cloned pixels. I even tried painting onto a new layer above it and it still showed through. I've never seen that before.
While this worked, I'm wary of doing it though because Photoshop forces a 16 bit OpenEXR to open as a 32-bit file. Then if you convert it to 16-bit it won't let you save back to an OpenEXR file type. You have to convert it back to 32-bit. So now all of my frames are 16-bit OpenEXR except for that one. Then the loader imports it as 16bit float. Maybe it isn't a problem at all, but I feel like with all that converting something bad probably happened
I think. Maybe not.
Thanks for your help, Rony.