Chroma key and PiP with Television Studio HD

Hello all,
I wonder if I can do a Chroma keying with a background of one of the media players and a picture in picture at the same time. If yes can you give me some advice how to do it? I sit here for hours already.

No this is not possible. The TVS HD Upstream keyer (USK) is needed for both functions. But you only have 1 of them in this mixer. That one of many limitations that this most cost effective mixer has.

When you need those 2 functions you need to buy an Atem 1ME which has 4 Upstream keyers.