Hi!
The Ultra Studio Express only has the option to use one input, but you can choose either to use HDMI or HDSDI. So, if you want to mix between them, you need a kind of mixer. I have an Ultra Studio Express myself, and one Blackmagic ATEM Television Studio (video mixer).
My setup with WireCast is connecting all cameras to the ATEM Television Studio mixer, and send one output (PGM) to Ultra Studio Express and further on with thunderbolt to the MacBook.
Camera -> HDSDI -> ATEM Televison Studio -> HDSDI -> Ultra Studio Express -> Thunderbolt -> MacBook -> Wirecast
Did that make any sense?