You won't end up with a migraine. If 8bit monitors causes migraine, everyone on a planet would have one
The most important thing is - do your job justify investing in true 10bit monitor? If you work mostly with 8bit footage, or even worse, if you just start to learn, then true 10bit monitor isn't yet for you. Only if money isn't an issue, then you shoud buy true 10bit monitor.
But if you want 10bit monitor as your reference monitor, then it is much better to invest in OLED TV (like LG C1 or CX series). That is much better investment in low budget colour grading monitor.
If you are buying monitor for GUI, 4K monitors are good in terms of realestate, but there are still (I don't know how to call it properly) some "issues" in DR with interface on high DPI monitors. You can check it here
viewtopic.php?f=21&t=126722
25 years in editing. On DR since v14
ASRock Steel Legend Z790
i7 13700k
64GB DDR5 5200
NVIDIA RTX 3090 24GB
Work: Firecuda 530 Star Wars Mandalorian 2TB
Cache: Firecuda 530 Star Wars Mandalorian 1TB
Render: Samsung 850 Pro 1TB SSD