CacheClip

What are the CacheClips for exactly? Can I delete these? I am running tight on my hard drive space and these take up considerable space. Thank you!

There are 3 contents (as I remember):
1: the GUID folder (for example b57e3bdd-e130-4210-9862-8bc28840a19b ) is the database temporary file store. In my experience they take up no space.
2: The Audio folder: The audio waveform files Resolve generates are stored here. If you have many long files with audio the folder can take up a lot of space (12 MB for an hour)
3: The Video folder (may not be called that). This folder is where the cache of your footage is stored when you create Render Cache, Timeline Proxy etc. My bet is this is the folder that takes up the most space.
No, neither of the folders are required per se, Resolve will generate the files again when it needs them.
(Disabling Render Cache and the like is the way not to have the folder use space, with the cost of potentially slower timeline performance)

From my experience cache files can safely be deleted manually for all completed projects.

Current cache files can be deleted via the project. If required they will be re made as requied by your project.

Resolve will rebuild Cache as needed.

That said, this work requires LOTS of space. It's better to accommodate that need than to try getting around it.

I recommend adding a large drive for Cache/Proxies/Gallery.

Thank you for the all the responses and explanations, I will follow these from going on.

cacheclip will fill up a Zettabyte of storage if you had it.

I regularly delete the whole thing to solve all sort of issues. You can also delete cache from DR but every now and then I do that from the OS and yes, it never caused me any issues. Obviously make sure DR is not running