Deleting The Cache—Does it Get Rebuilt?

I have allowed my cache to grow to enormous proportions.
If I delete the contents of the cache folder, will the cache for a particular project get rebuilt when I reopen it? Or will all my work be lost?
I know the answer is likely in the manual, but I was hoping for real-world validation.
Thanks
If I delete the contents of the cache folder, will the cache for a particular project get rebuilt when I reopen it? Or will all my work be lost?
I know the answer is likely in the manual, but I was hoping for real-world validation.
Thanks