Having done exactly that last weekend I can say you do need to think about your workflow. Its very easy to get "lost in the desks".
The upside is you get multiple keying, multiple DVE's and 8 HDMI inputs - important for us as we need more than 4 PC inputs. Where as the 2ME "only"

has 4 HDMI and 12 HD-SDI.
Also the second switcher happily works from the laptop, I dont need to get much more creative than selecting the next input and hitting take.
I would love a "simple" button box though (similar to the Matrix control panels) that just has say, a preview row and a take button.

Taken during setup and testing at Multiplay's Insomnia46 gaming festival here in the UK. I love my job, I get to play with so many toys

Stage 1 and 2 inputs on the left hand screen are actually AUX 1 and 2 from the right hand screens broadcast panel (physically located backstage). This allows me to solo an input on the BOH desk and get it permanently to my FOH desk during the smaller parts of the show so I can "set and forget" and just use the physical control surface.